منابع مشابه
Skipping Refinement
We introduce skipping refinement, a new notion of correctness for reasoning about optimized reactive systems. Reasoning about reactive systems using refinement involves defining an abstract, highlevel specification system and a concrete, low-level implementation system. One then shows that every behavior allowed by the implementation is also allowed by the specification. Due to the difference i...
متن کاملSkipping Streams with XHints
When streaming semi-structured data is processed by a well-designed query processor, parsing constitutes a significant portion of the running time. Further improvements in performance therefore require some method to overcome the high cost of parsing. We have designed a general-purpose mechanism by which a producer of streaming data may augment the data stream with hints that permit a downstrea...
متن کاملExon skipping for DMD
Duchenne muscular dystrophy (DMD) is a severe, progressive muscle-wasting disorder, while Becker muscular dystrophy (BMD) is milder muscle disease [1]. Both are caused by mutations in dystrophin, a protein, which stabilizes muscle fibers during contraction by linking muscle actin to the extracellular matrix. In DMD patients mutations disrupt the open reading frame, generating prematurely trunca...
متن کاملExon Skipping Therapy
Exondys 51 is the first therapy for Duchenne muscular dystrophy (DMD) to have been granted accelerated approval by the FDA. Approval was granted based on using dystrophin expression as a surrogate marker. Exondys 51 targets DMD exon 51 for skipping to restore the reading frame for 13% of Duchenne patients.
متن کاملStability in skipping gaits
As an alternative to walking and running, humans are able to skip. However, adult humans avoid it. This fact seems to be related to the higher energetic costs associated with skipping. Still, children, some birds, lemurs and lizards use skipping gaits during daily locomotion. We combined experimental data on humans with numerical simulations to test whether stability and robustness motivate thi...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 1997
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.4883